PulseSensor Research (C2)

Research

PulseSensor Research

The weird, cool science under the open hardware. A working reading list for anyone pushing PPG past beats-per-minute — respiration, signal quality, and the algorithms that get you there.

The maker world is rich in mash-ups of tech and technique, and a little thin on the underlying science. This section is our attempt to fix that. It is not a product page and nothing here is a claim about what PulseSensor measures. It is the literature we read, the papers we hand to people who ask "how would I actually do that?", and the open-access links to go read them yourself.

For creative, educational, and experimental use. PulseSensor is not a medical device and is not for medical use. Nothing in this section is medical advice.

Advanced PPG signal processing

An annotated bibliography, with emphasis on extracting respiration from the PPG signal

Scope note (from the author). This bibliography, prepared with AI-assistance, is intended for a practical research program involving Arduino/ESP32-style multi-channel PPG acquisition, respiratory-rate extraction, respiratory-waveform derivation, signal-quality assessment, artifact rejection, and validation against respiratory reference signals. The emphasis is on PubMed-indexed and PubMed Central/open-access material where possible, while retaining several older or paywalled papers that are scientifically central.

The short version

The literature treats the PPG as a cardiovascular carrier signal modulated by respiration. Respiratory information appears as respiratory-induced amplitude variation (RIAV), intensity or baseline variation (RIIV), frequency variation through respiratory sinus arrhythmia (RIFV), pulse-width and morphology changes, slow baseline shifts, and site-dependent venous/arterial interactions.

The practical consequence for anyone building on an Arduino or ESP32: store raw waveforms and metadata, and support several parallel respiratory channels rather than one estimator. Pick a single method too early and you will spend months tuning a number that a second channel would have told you not to trust.

Where to start

Forty-seven papers is a lot. If you read them in this order, each one makes the next easier.

Order Paper Why this one first
1 Charlton et al. 2018 review Organizing framework for the entire field of ECG/PPG breathing-rate estimation.
2 Pimentel et al. 2017 Robust pulse-oximeter RR estimation with quality assessment and fusion.
3 Karlen et al. 2013 Classic multiparameter RIAV/RIIV/RIFV estimator.
4 Dehkordi et al. 2018 Instantaneous RR from multiple respiratory-induced PPG variations.
5 Hartmann et al. 2019 Measurement-site effects; directly informs sensor placement.
6 Elgendi 2016; Orphanidou 2015; Jarchi et al. 2019 Signal quality and motion contamination, essential for wearable or Arduino experiments.
7 Baker et al. 2021; Iqbal et al. 2022; Chin et al. 2024 Modern algorithmic and machine-learning extensions.
8 Charlton et al. 2022 and 2023 Roadmap-level guidance for open wearable PPG systems.

Reading the open-access labels

Every entry below is tagged with how far you can get without a library card.

Label Meaning Practical implication
Open access (PMC) Full text visible in PubMed Central, or open from an OA publisher. Best candidate for teaching packets, reproducible review, and full methodological study. Check the license before reusing figures.
Free to read Free copy, author manuscript, or institutional PDF located — but not a formal OA record. Fine for reading; verify copyright and license before redistributing.
Abstract only Important record found, but open full text was not confirmed in this pass. Use the abstract and citation; obtain through a library if you need the full paper.

The bibliography

Forty-seven entries in four groups. Citations and commentary are the author's; we have only laid them out.

47 of 47 shown

Foundational PPG reviews and roadmaps

Start here if PPG is new to you. Physiology, instrumentation, error sources, and where the wearable field is headed.

1.Allen J. Photoplethysmography and its application in clinical physiological measurement. Physiological Measurement. 2007;28(3):R1-R39. doi:10.1088/0967-3334/28/3/R01. PMID:17322588.

A classic entry point for PPG physiology and instrumentation. It remains useful because respiratory extraction depends on understanding the arterial, venous, autonomic, optical-coupling, and site-related sources of waveform variation.

Abstract onlyPubMed

2.Castaneda D, Esparza A, Ghamari M, Soltanpur C, Nazeran H. A review on wearable photoplethysmography sensors and their potential future applications in health care. International Journal of Biosensors & Bioelectronics. 2018;4(4):195-202. doi:10.15406/ijbsbe.2018.04.00125.

Broad wearable-PPG review emphasizing sensor configurations, motion artifact, measurement site, and applications. Useful for choosing between finger, ear, forehead, wrist, and reflectance/transmission modes.

Open access (PMC)PMC

3.Tamura T. Current progress of photoplethysmography and SpO2 for health monitoring. Biomedical Engineering Letters. 2019;9(1):21-36. doi:10.1007/s13534-019-00097-w. PMID:30956885.

Concise review of PPG and pulse-oximetry technology, including motion artifacts and health-monitoring applications. A useful bridge between clinical pulse oximetry and consumer/wearable PPG.

Open access (PMC)PMC

4.Fine J, Branan KL, Rodriguez AJ, Boonya-ananta T, Ajmal, Ramella-Roman JC, McShane MJ, Cote GL. Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring. Biosensors (Basel). 2021;11(4):126. doi:10.3390/bios11040126. PMID:33923469.

Highly relevant to experimental design. It catalogs sources of error including skin tone, motion, contact pressure, ambient light, sensor position, and physiology; all of these can corrupt respiratory-induced modulation.

Open access (PMC)PMC

5.Mejia-Mejia E, Budidha K, Abay TY, May JM, Kyriacou PA. Photoplethysmography Signal Processing and Synthesis. In: Kyriacou PA, Allen J, editors. Photoplethysmography: Technology, Signal Analysis and Applications. Academic Press; 2022.

Practical technical chapter on PPG preprocessing, time-domain analysis, frequency-domain analysis, machine learning, and synthetic signal generation. Valuable for moving from pulse counting to respiratory modulation extraction and simulator-driven testing.

Free to readAuthor PDF

6.Park J, Seok HS, Kim SS, Shin H. Photoplethysmogram Analysis and Applications: An Integrative Review. Frontiers in Physiology. 2022;12:808451. doi:10.3389/fphys.2021.808451. PMID:35222266.

Broad modern review of PPG analysis, physiology, and applications. It helps place respiratory extraction alongside HRV, blood pressure estimation, vascular assessment, autonomic analysis, and wearable sensing.

Open access (PMC)PMC

7.Charlton PH, Kyriacou PA, Mant J, Marozas V, Chowienczyk P, Alastruey J. Wearable Photoplethysmography for Cardiovascular Monitoring. Proceedings of the IEEE. 2022;110(3):355-381. doi:10.1109/JPROC.2022.3149785. PMID:35356509.

High-value review for wearable and low-cost PPG systems. Covers sensor design, preprocessing, signal quality, datasets, and clinical use; essential background for respiratory algorithms in wearable conditions.

Open access (PMC)PMC

8.Charlton PH, et al. The 2023 wearable photoplethysmography roadmap. Physiological Measurement. 2023;44(11):111001. doi:10.1088/1361-6579/acead2. PMID:37494945.

Strategic roadmap for wearable PPG research: sensor design, signal processing, clinical translation, datasets, bias, and open science. Strong reference for building an open Arduino/ESP32 PPG platform.

Open access (PMC)PMC

Respiratory physiology and PPG modulation

Why breathing shows up in a heartbeat signal at all — venous return, intrathoracic pressure, autonomic effects, RSA.

9.Meredith DJ, Clifton D, Charlton PH, Brooks J, Pugh CW, Tarassenko L. Photoplethysmographic derivation of respiratory rate: a review of relevant physiology. Journal of Medical Engineering & Technology. 2012;36(1):1-7. doi:10.3109/03091902.2011.638965. PMID:22185462.

Foundational physiological review explaining how breathing modulates PPG through venous return, intrathoracic pressure, autonomic effects, and respiratory sinus arrhythmia. Justifies parallel extraction of RIIV, RIAV, and RIFV.

Free to readAuthor PDF

10.Nilsson LM. Respiration signals from photoplethysmography. Anesthesia & Analgesia. 2013;117(4):859-865. doi:10.1213/ANE.0b013e31828098b2. PMID:23449854.

Clinically oriented review from anesthesia and monitoring. Particularly relevant to OR and procedural settings where pulse oximetry is already present and respiration monitoring may be desirable without extra sensors.

Abstract onlyPubMed

11.Li J, Jin J, Chen X, Sun W, Guo P. Comparison of respiratory-induced variations in photoplethysmographic signals. Physiological Measurement. 2010;31(3):415-425. doi:10.1088/0967-3334/31/3/009. PMID:20147775.

Important comparison of respiratory-induced PPG variations. Supports storing raw waveform data so that multiple modulation families can be compared offline rather than relying on one respiratory surrogate.

Abstract onlyPubMed

12.Liu H, et al. Comparison of different modulations of photoplethysmography in extracting respiratory rate: from a physiological perspective. Physiological Measurement. 2020;41(9):094001. doi:10.1088/1361-6579/abaaf0. PMID:32731213.

Corrected title. Useful because it frames respiratory extraction in terms of physiological mechanisms rather than numerical performance alone. It reminds developers that amplitude, baseline, and frequency modulation may fail under different conditions.

Abstract onlyPubMed

13.Hartmann V, Liu H, Chen F, Qiu Q, Hughes S, Zheng D. Toward Accurate Extraction of Respiratory Frequency From the Photoplethysmogram: Effect of Measurement Site. Frontiers in Physiology. 2019;10:732. doi:10.3389/fphys.2019.00732. PMID:31316390.

Directly relevant to hardware design. Shows that PPG-derived respiratory frequency depends on measurement site and breathing pattern; strongly supports testing multiple sensor locations or optical channels.

Open access (PMC)PMC

14.Addison PS. Respiratory modulations in the photoplethysmogram (DPOP) as a measure of respiratory effort. Journal of Clinical Monitoring and Computing. 2016;30(5):595-602. doi:10.1007/s10877-015-9763-y. PMID:26377021.

Useful for moving beyond respiratory rate toward respiratory effort. DPOP quantifies the strength of respiratory modulation in the pleth waveform; a platform should consider modulation depth as well as rate.

Open access (PMC)PMC

15.Addison PS. Respiratory effort from the photoplethysmogram. Medical Engineering & Physics. 2017;41:9-18. doi:10.1016/j.medengphy.2016.12.010. PMID:28126420.

Explores candidate PPG-derived parameters for respiratory effort, including amplitude, baseline, frequency, and pulse-transit-related changes. Suggests richer endpoints than respiratory rate alone.

Free to readPubMed

Classical and advanced algorithmic extraction

The signal-processing toolbox: filtering, time-frequency analysis, synchrosqueezing, and probabilistic fusion.

16.Nakajima K, Tamura T, Miike H. Monitoring of heart and respiratory rates by photoplethysmography using a digital filtering technique. Medical Engineering & Physics. 1996;18(5):365-372. doi:10.1016/1350-4533(95)00066-6. PMID:8762834.

Historically important early demonstration that both heart and respiratory rates can be extracted from PPG with digital filtering. Dated technologically, but conceptually useful as a simple baseline.

Abstract onlyPubMed

17.Chon KH, Dash S, Ju K. Estimation of respiratory rate from photoplethysmogram data using time-frequency spectral estimation. IEEE Transactions on Biomedical Engineering. 2009;56(8):2054-2063. doi:10.1109/TBME.2009.2019766. PMID:19369147.

Key paper in the transition from simple filtering to time-frequency spectral estimation. Important for nonstationary breathing; a good offline benchmark against cheaper embedded algorithms.

Free to readPubMed

18.Karlen W, Raman S, Ansermino JM, Dumont GA. Multiparameter respiratory rate estimation from the photoplethysmogram. IEEE Transactions on Biomedical Engineering. 2013;60(7):1946-1953. doi:10.1109/TBME.2013.2246160. PMID:23399950.

Central paper for PPG-derived respiratory rate. It extracts respiratory-induced frequency, intensity, and amplitude variations and combines information across them; highly relevant to a multi-channel platform.

Abstract onlyPubMed

19.Charlton PH, Bonnici T, Tarassenko L, Clifton DA, Beale R, Watkinson PJ. An assessment of algorithms to estimate respiratory rate from the electrocardiogram and photoplethysmogram. Physiological Measurement. 2016;37(4):610-626. doi:10.1088/0967-3334/37/4/610. PMID:27027672.

Methodological cornerstone comparing algorithms and emphasizing validation, data quality, and common evaluation methods. Important antidote to overfitting algorithms to one clean dataset.

Open access (PMC)PMC

20.Pimentel MAF, Johnson AEW, Charlton PH, Birrenkott D, Watkinson PJ, Tarassenko L, Clifton DA. Toward a Robust Estimation of Respiratory Rate From Pulse Oximeters. IEEE Transactions on Biomedical Engineering. 2017;64(8):1914-1923. doi:10.1109/TBME.2016.2613124. PMID:28113393.

Must-read for robust RR estimation from pulse oximetry. Uses respiratory-induced variations, quality assessment, and probabilistic fusion; one of the best algorithmic templates for a practical platform.

Open access (PMC)PMC

21.Charlton PH, Birrenkott DA, Bonnici T, Pimentel MAF, Johnson AEW, Alastruey J, Tarassenko L, Watkinson PJ, Beale R, Clifton DA. Breathing Rate Estimation From the Electrocardiogram and Photoplethysmogram: A Review. IEEE Reviews in Biomedical Engineering. 2018;11:2-20. doi:10.1109/RBME.2017.2763681. PMID:29990026.

The best single review for breathing-rate estimation from ECG and PPG. Lays out preprocessing, respiratory-signal extraction, rate estimation, fusion, and quality assessment.

Open access (PMC)PMC

22.Garde A, Karlen W, Ansermino JM, Dumont GA. Estimating respiratory and heart rates from the correntropy spectral density of the photoplethysmogram. PLOS ONE. 2014;9(1):e86427. doi:10.1371/journal.pone.0086427. PMID:24466088.

Corrected author list: Dehkordi was removed. Uses correntropy spectral density to improve robustness to noise and non-Gaussian artifacts; useful when simple FFT/Welch methods are unreliable.

Open access (PMC)PMC

23.Park C, Lee B, Lee J. Real-time estimation of respiratory rate from a photoplethysmogram using an adaptive lattice notch filter. BioMedical Engineering OnLine. 2014;13:170. doi:10.1186/1475-925X-13-170. PMID:25518918.

Corrected title and venue. Valuable for real-time feasibility: algorithms that work in MATLAB may be too memory- or CPU-intensive for an embedded device.

Open access (PMC)PMC

24.Zhang X, Ding Q. Respiratory rate monitoring from the photoplethysmogram via sparse signal reconstruction. Physiological Measurement. 2016;37(7):1105-1119. doi:10.1088/0967-3334/37/7/1105. PMID:27319303.

Corrected full citation. Treats respiration as a sparse spectral component embedded in a stronger cardiac carrier and noise; likely more useful as an offline benchmark than a first Arduino algorithm.

Abstract onlyPubMed

25.Dehkordi P, Garde A, Karlen W, Ansermino JM, Dumont GA. Estimating instantaneous respiratory rate from the photoplethysmogram. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2015;2015:6150-6153. doi:10.1109/EMBC.2015.7319796. PMID:26737696.

Corrected conference citation. Introduces a synchrosqueezing-transform direction for instantaneous respiratory-rate extraction; likely too heavy for first-pass embedded use but a valuable offline standard.

Abstract onlyPubMed

26.Dehkordi P, Garde A, Karlen W, Wensley D, Ansermino JM, Dumont GA. Extracting Instantaneous Respiratory Rate From Multiple Photoplethysmogram Respiratory-Induced Variations. Frontiers in Physiology. 2018;9:948. doi:10.3389/fphys.2018.00948. PMID:30131724.

Central open-access paper for advanced respiratory extraction. Extracts RIIV, RIAV, and RIFV, estimates instantaneous RR from each, and fuses estimates.

Open access (PMC)PMC

27.Cicone A, Wu HT. How nonlinear-type time-frequency analysis can help in sensing instantaneous heart rate and instantaneous respiratory rate from photoplethysmography in a reliable way. Frontiers in Physiology. 2017;8:701. doi:10.3389/fphys.2017.00701. PMID:29018395.

Mathematically advanced nonlinear time-frequency analysis for instantaneous heart and respiratory rates. Not a first embedded method, but useful as a high-end reference standard.

Open access (PMC)PMC

28.Khreis S, Ge D, Rahman HA, Carrault G. Breathing Rate Estimation Using Kalman Smoother With Electrocardiogram and Photoplethysmogram. IEEE Transactions on Biomedical Engineering. 2020;67(3):893-904. doi:10.1109/TBME.2019.2923448. PMID:31217092.

Shows the value of temporal tracking/smoothing for breath-rate estimates. A Kalman or Bayesian smoother is a natural second-stage module after raw estimator extraction.

Abstract onlyPubMed

29.Iqbal T, Elahi A, Ganly S, Wijns W, Shahzad A. Photoplethysmography-Based Respiratory Rate Estimation Algorithm for Health Monitoring Applications. Journal of Medical and Biological Engineering. 2022;42(2):242-252. doi:10.1007/s40846-022-00700-z. PMID:35535218.

Corrected full citation. Practical algorithm using selective windowing, preprocessing, modified Welch filtering, and postprocessing. A useful baseline because it is less exotic than synchrosqueezing but more robust than simple filtering.

Open access (PMC)PMC

30.Kim H, Lee HJ, Kim JS, Whang MC. Fast and Robust Real-Time Estimation of Respiratory Rate from Photoplethysmography. Sensors (Basel). 2016;16(9):1494. doi:10.3390/s16091494. PMID:27649195.

Added as a useful correction/augmentation. Proposes fast real-time RR estimation from PPG, relevant to low-resource embedded implementations and comparison with Park-style adaptive filtering.

Open access (PMC)PMC

31.Pirhonen M, Peltokangas M, Vehkaoja A. Acquiring Respiration Rate from Photoplethysmographic Signal by Recursive Bayesian Tracking of Intrinsic Modes in Time-Frequency Spectra. Sensors (Basel). 2018;18(6):1693. doi:10.3390/s18061693. PMID:29843380.

Useful open-access time-frequency/Bayesian tracking paper. It broadens the algorithmic menu beyond RIAV/RIIV/RIFV and standard spectral peaks.

Open access (PMC)PMC

Machine learning, signal quality, and robustness

Deep learning approaches, signal-quality indices, and staying honest when the data is noisy.

32.Baker S, Xiang W, Atkinson I. Determining respiratory rate from photoplethysmogram and electrocardiogram signals using respiratory quality indices and neural networks. PLOS ONE. 2021;16(4):e0249843. doi:10.1371/journal.pone.0249843. PMID:33891653.

Strong bridge between classical modulation extraction and neural networks. Emphasizes respiratory signal quality quantification before feeding information into models.

Open access (PMC)PMC

33.Lei R, Chen C, Zhou C, Zhang Y, Yang Z, Wang X. Estimation of Heart Rate and Respiratory Rate from PPG Signal Based on Complementary Ensemble Empirical Mode Decomposition with Adaptive Noise and Independent Component Analysis. Sensors (Basel). 2020;20(11):3237. doi:10.3390/s20113237. PMID:32517009.

Uses decomposition and source-separation style processing to recover heart and respiratory rates. Useful for comparing EMD/ICA approaches with simpler bandpass methods.

Open access (PMC)PMC

34.Chowdhury MH, Shuzan MNI, Chowdhury MEH, Reaz MBI, Mahmud S, Al Emadi N, et al. Lightweight End-to-End Deep Learning Solution for Estimating the Respiration Rate from Photoplethysmogram Signal. Bioengineering (Basel). 2022;9(10):558. doi:10.3390/bioengineering9100558.

Corrected title and venue. Useful as a benchmark for direct RR estimation from raw/processed PPG, even if a full deep model is not the first target for Arduino deployment.

Open access (PMC)PMC

35.Hwang CS, et al. Evaluation of the Photoplethysmogram-Based Deep Learning Model for Respiratory Rate Estimation. Sensors (Basel). 2023;23(20):8377. doi:10.3390/s23208377. PMID:37892952.

Corrected to a specific Sensors article. Evaluates deep learning models for continuous RR estimation from PPG and helps identify what labeled respiratory reference signal would be needed for training or validation.

Open access (PMC)PMC

36.Shuzan MNI, Chowdhury MH, Chowdhury MEH, Murugappan M, Bhuiyan EH, Ayari MA, Khandakar A. Machine Learning-Based Respiration Rate and Blood Oxygen Saturation Estimation Using Photoplethysmogram Signals. Bioengineering (Basel). 2023;10(2):167. doi:10.3390/bioengineering10020167. PMID:36829661.

Machine-learning approach to estimating both RR and SpO2-related information from PPG. Suggests future multi-output models that estimate RR, signal quality, SpO2 surrogates, and artifact flags.

Open access (PMC)PMC

37.Chin WJ, Kwan BH, Lim WY, Tee YK, Darmaraju S, Liu H, Goh CH. A novel respiratory rate estimation algorithm from photoplethysmogram using deep learning model. Diagnostics (Basel). 2024;14(3):284. doi:10.3390/diagnostics14030284. PMID:38337800.

Corrected title. Recent open-access paper explicitly focused on RR from PPG; useful contemporary comparator and bridge to older RIAV/RIIV/RIFV methods.

Open access (PMC)PMC

38.Yang G, Kang Y, Charlton PH, Kyriacou PA, Kim KK, Li L, Park C. Energy-Efficient PPG-Based Respiratory Rate Estimation Using Spiking Neural Networks. Sensors (Basel). 2024;24(12):3980. doi:10.3390/s24123980. PMID:38931569.

Relevant for low-power and embedded ambitions. Spiking neural networks may eventually map well to efficient hardware, even if not immediately Arduino-friendly.

Open access (PMC)PMC

39.Arguello-Prada EJ, et al. The use of successive systolic differences in photoplethysmography for respiratory rate estimation. Heliyon. 2024;10(2):e24576. doi:10.1016/j.heliyon.2024.e24576.

Introduces respiratory-induced variations in successive systolic differences as an alternative to classic amplitude, intensity, and frequency families; valuable for beat-to-beat morphology-oriented experiments.

Open access (PMC)PMC

40.Ponsiglione AM, et al. Comparison of Techniques for Respiratory Rate Extraction from ECG and PPG Signals. Sensors (Basel). 2025;25(16):5136. doi:10.3390/s25165136. PMID:40871998.

Recent comparative paper evaluating extraction from ECG and PPG. Useful for sober benchmarking and for recognizing conditions where PPG-derived respiration may underperform ECG-derived features.

Open access (PMC)PMC

41.Jarchi D, Charlton PH, Pimentel MAF, Casson AJ, Tarassenko L, Clifton DA. Estimation of Respiratory Rate from Motion Contaminated Photoplethysmography Signals Incorporating Accelerometry. Healthcare Technology Letters. 2019;6(1):19-24. doi:10.1049/htl.2018.5019.

Corrected full title. Motion-contaminated PPG is the normal wearable case; supports adding accelerometers and explicit motion labels to the platform.

Open access (PMC)PMC

42.Lee J, Kim M, Park HK, Kim IY. Motion Artifact Reduction in Wearable Photoplethysmography Based on Multi-Channel Sensors with Multiple Wavelengths. Sensors (Basel). 2020;20(5):1493. doi:10.3390/s20051493.

Directly relevant to hardware. Supports multi-channel and multi-wavelength PPG sensors for artifact reduction; useful for separating respiratory physiology from motion and contact artifacts.

Open access (PMC)PMC

43.Elgendi M. Optimal Signal Quality Index for Photoplethysmogram Signals. Bioengineering (Basel). 2016;3(4):21. doi:10.3390/bioengineering3040021. PMID:28952542.

Key open paper on PPG signal-quality indices. Respiratory extraction is only as reliable as the source waveform; supports quality gating before RR estimation.

Open access (PMC)PMC

44.Sabeti E, Reamaroon N, Mathis J, et al. Signal quality measure for pulsatile physiological signals using morphological features: Applications in reliability measure for pulse oximetry. Informatics in Medicine Unlocked. 2019;16:100222. doi:10.1016/j.imu.2019.100222. PMID:32864419.

Corrected title and application phrase. Proposes morphological features for signal quality and reliability, which can support exclusion/down-weighting of unreliable PPG windows.

Open access (PMC)PMC

45.Orphanidou C, Bonnici T, Charlton P, Clifton D, Vallance D, Tarassenko L. Signal-quality indices for the electrocardiogram and photoplethysmogram: derivation and applications to wireless monitoring. IEEE Journal of Biomedical and Health Informatics. 2015;19(3):832-838. doi:10.1109/JBHI.2014.2338351. PMID:25069129.

Highly cited SQI paper in wearable monitoring. Reinforces that signal quality is task-specific: a segment may be adequate for heart rate but not for respiratory information.

Abstract onlyPubMed

46.van Gastel M, Stuijk S, de Haan G. Robust respiration detection from remote photoplethysmography. Biomedical Optics Express. 2016;7(12):4941-4957. doi:10.1364/BOE.7.004941. PMID:28018717.

Remote/camera-based PPG paper relevant because it extracts respiration from color/intensity variations and addresses motion robustness. Broadens the project from contact PPG to optical/camera respiratory sensing.

Open access (PMC)PMC

47.Zhang Y, Song S, Vullings R, Biswas D, Simões-Capela N, Van Helleputte N, Van Hoof C, Groenendaal W. Motion Artifact Reduction for Wrist-Worn Photoplethysmograph Sensors Based on Different Wavelengths. Sensors (Basel). 2019;19(3):673. doi:10.3390/s19030673. PMID:30764575.

Useful adjunct for multi-wavelength hardware design. Although focused mainly on heart-rate recovery, the motion-removal logic matters for any respiratory estimator using wearable PPG.

Open access (PMC)Link

Applied: what this means for a PulseSensor

Everything above is literature. This section is the bridge: what each idea means when the sensor in your hand is a PulseSensor, on a real finger, in a room with real light in it.

What the sensor actually does

PulseSensor is a reflectance photoplethysmograph. A green LED shines into the tissue, a photodiode measures how much light comes back, and an onboard amplifier and filter turn that into an analog voltage your board samples. Blood volume rises with each heartbeat, absorbs slightly more light, and the returned signal dips. That is the whole trick — and every paper above is, at bottom, about what else is riding on that one wobbling line.

See Entries 1 and 2.

Why respiration is in there at all

Breathing changes intrathoracic pressure and venous return, and the autonomic system modulates heart rate in time with the breath. So the pulse waveform carries at least three respiratory fingerprints: amplitude (RIAV), baseline (RIIV), and rate (RIFV, or respiratory sinus arrhythmia). They are small, they are simultaneous, and they do not always agree.

See Entries 9, 18 and 26.

Where you put it changes what you get

Site Why use it What bites you
Fingertip Strongest, most forgiving signal. The default for a reason. Cold hands kill perfusion. Hands move constantly. Our stabilizer ring exists for exactly this.
Earlobe Much steadier than a finger. Well suited to breathing work where you need a quiet baseline. Smaller signal amplitude. Needs a clip to stay put. The kit ear clip.
Forehead Good perfusion, and a favourite in the respiratory literature. Very sensitive to contact pressure. Easy to press too hard and occlude what you are trying to measure. Light shield helps.
Wrist The realistic wearable position, which is why most modern papers use it. Weakest signal and the worst motion artifact of the four. Expect to fight for this one.
Hartmann et al. (entry 13) is the paper to read here: PPG-derived respiratory frequency measurably depends on where you put the sensor and how the subject is breathing. If you are comparing algorithms without logging measurement site, you are comparing noise.

Skin, pressure, light, and motion

Error source What happens What helps
Skin tone Melanin absorbs green light. Darker skin returns less signal at PulseSensor's wavelength, so amplitude — not heart rate, but amplitude — varies between people. This is a documented property of green-wavelength reflectance PPG across the whole industry, not a quirk of one sensor. Longer averaging, better light shielding, and firm-but-not-hard contact. Longer wavelengths are the real fix, which is why multi-wavelength work is interesting to us.
Contact pressure Press too lightly and the sensor floats. Press too hard and you occlude the very blood flow you are measuring. There is a window, and it is narrower than people expect. Mechanical fixturing beats willpower. Ring, clip, or strap.
Ambient light The photodiode cannot tell your heartbeat from a flickering ceiling light. Mains-frequency hum and daylight both intrude. Shield the sensor. Then check your spectrum for a 50 or 60 Hz spike before blaming your algorithm.
Motion The dominant artifact in every wearable PPG paper in this list. Motion energy overlaps the respiratory band, which is precisely the band you want. An accelerometer is the cheapest upgrade you can make to a PPG rig. You cannot subtract what you did not measure.
Fine et al. (entry 4, open access) catalogs all of these in one place — skin tone, motion, contact pressure, ambient light, sensor position, and physiology. If you read one paper before building an experiment, read that one.

Knowing when to trust a window

Signal quality is task-specific. A window clean enough to count beats is often far too dirty to pull a breathing rate out of, because respiration lives in the small modulations that motion destroys first. The signal-quality index literature (entries 43, 44 and 45) exists to let your code know the difference. Gate first, estimate second, and log which windows you threw away.

What you can build with one, two, or three sensors

The bibliography gets considerably more useful once you know which parts of it you can actually act on today. Roughly, capability steps up with channel count.

One sensor — The single-channel workbench

  • Beats per minute and inter-beat interval — Straight out of PulseSensor Playground — getBeatsPerMinute() and getInterBeatIntervalMs().
  • Heart rate variability — Time domain, frequency domain, and Poincaré phase-space plots from the IBI series alone.
  • Live FFT of the pulse waveform — Spectral view of your own pulse. Where the respiratory band starts becoming visible.
  • Respiration from one channel — RIAV, RIIV and RIFV all extractable from a single PPG trace — entries 18 and 26 are the templates.
  • Biofeedback — Close the loop: paced breathing against your own live HRV.

Two sensors — Time-of-flight and A/B

  • Pulse transit time — Two sensors at different distances from the heart give you the travel time of the pressure wave between them.
  • Site comparison, properly controlled — Finger against earlobe on the same person at the same moment — the experiment entry 13 says you need to run.
  • Left-right symmetry — Same site, both sides. Differences are interesting; so is the absence of them.
  • Common-mode motion rejection — What shows up in both channels is the body moving. What shows up in one is local. This is the cheapest artifact discriminator there is.

Three or more — Fusion territory

  • Multi-channel respiratory fusion — Run several respiratory estimators in parallel and combine them with quality weighting — the approach in entries 20, 21 and 26. This is where single-estimator setups stop being competitive.
  • Multi-wavelength artifact reduction — Entries 42 and 47 show different wavelengths responding differently to motion, which lets you separate physiology from movement.
  • Spatial and propagation mapping — Three or more sites along a limb turn a timing measurement into a picture of how the wave travels.
  • A non-PPG channel — An accelerometer is not a PulseSensor, but it is the highest-value third channel you can add. Motion ground truth makes every other estimator better.

Honest limits

One wavelength means no SpO2. Pulse oximetry needs at least two wavelengths — typically red and infrared — to separate oxygenated from deoxygenated haemoglobin. PulseSensor is single-wavelength green. Nothing in this bibliography changes that, and any project claiming SpO2 from a single green channel is mistaken.
Your ADC sets your ceiling. PulseSensor hands your board an analog voltage. Sample rate, ADC bit depth, and reference stability are yours to get right. Several methods in the algorithms section assume a clean, evenly-timed sample stream and quietly fall apart without one.
None of this is medical. These are educational and experimental instruments. The clinical papers here describe what the research literature has established in clinical settings with clinical equipment; they are not instructions for measuring anyone's health. PulseSensor is not a medical device and is not for diagnosis, treatment, monitoring, or emergency use.

Notes for an Arduino / ESP32 platform

Reading the papers above with a breadboard in front of you, a few practical rules keep showing up:

  • Save the raw waveform. Every respiratory method in this list works on raw samples. Anything you throw away at capture time you cannot get back.
  • Start with bandpass filtering and spectral peak detection, then layer RIAV, RIIV, and RIFV extraction on top — not instead.
  • Gate on signal quality, then fuse. A window that is good enough for heart rate is often not good enough for respiration. The SQI papers in section four exist for exactly this.
  • Plan for an accelerometer and, eventually, multiple wavelengths. Motion is the dominant artifact, and it is much easier to reject when you have measured it.
  • Log measurement site. Finger, earlobe, and forehead do not behave the same way — see Hartmann et al. 2019.

Already on this site

We have been publishing hands-on signal work for years. These pages are the practical companion to the reading list.

Heart rate variability

Our four-part walk through HRV with a PulseSensor and Processing.

Multi-sensor experiments

Where a second sensor starts telling you things one cannot.

Build on it

The reason this reading list belongs on this site and not in a folder somewhere: everything it describes is implementable against code we already give away. A decade of Arduino libraries, Processing and p5.js sketches, worked examples, and documentation — MIT licensed, all of it.

Working on PPG research with a PulseSensor? We would like to hear about it — and to link to it.

This bibliography was prepared with AI assistance and is offered for creative, educational, and experimental use. PulseSensor is not a medical device and is not for diagnosis, treatment, monitoring, or emergency use. Citations and commentary are reproduced with the author's permission; errors in layout are ours.

Compiled by D. John Doyle for World Famous Electronics. Free and open-source hardware since 2011.