Research G2 — Applied Multi-Sensor PPG Bibliography

PulseSensor Research · Complete working bibliography

Photoplethysmography Annotated Bibliography

A practical roadmap through 47 scientific papers about the information carried inside the PPG signal—with particular emphasis on extracting respiration.

From Dr. D. John Doyle

This annotated scientific bibliography offers a focused, practical roadmap for researchers and developers engaged in advanced signal processing of the photoplethysmograph (PPG) signal, with particular emphasis on the extraction of respiratory information. PPG, a non-invasive optical technique widely embedded in pulse oximeters and wearable devices, captures volumetric changes in blood flow and serves as a rich cardiovascular carrier signal subtly modulated by respiration.

The bibliography curates key literature—prioritizing PubMed-indexed and open-access sources—essential for building experimental platforms using low-cost hardware like Arduino or ESP32. It addresses the full pipeline: multi-channel PPG acquisition, respiratory-rate estimation, derivation of respiratory waveforms, signal-quality assessment, artifact rejection, and validation against reference signals such as capnography or impedance pneumography.

At its core, the collection recognizes respiration as a multifaceted modulator of the PPG waveform. Rather than relying on a single estimator, it advocates storing raw waveforms and metadata so several respiratory surrogates can be processed and combined in parallel.

RIAVRespiratory-induced amplitude variation
RIIVRespiratory-induced intensity or baseline variation
RIFVRespiratory-induced frequency variation

The familiar PulseSensor starting point

From reflected light to heartbeat, BPM and HRV

Before looking for respiration, it helps to follow the traditional PulseSensor signal chain. PulseSensor is a reflectance photoplethysmograph: its green sensing LED shines into the tissue, and a photodetector measures the changing amount of light reflected back as each arterial pulse changes the local blood volume. The electronics turn that optical change into a continuously varying analog voltage—the raw PPG waveform.

The PulseSensor Playground code samples that waveform at 500 Hz. It follows the rising edge and changing amplitude of the pulse wave to identify qualified beats, measures the milliseconds between beats as the inter-beat interval (IBI), and derives beats per minute (BPM). A built-in or external feedback LED—including the red LED on the PulseSensor CyberDeck—can then flash or fade on each qualified beat.

1 · IlluminateGreen LEDLight enters fingertip or earlobe tissue.
2 · DetectReflected lightBlood-volume changes modulate the returned light.
3 · ObserveRaw PPG waveAn analog voltage traces pulse shape and morphology.
4 · MeasureBeat · IBI · BPMQualified beat timing produces intervals and heart rate.
5 · ExploreHRV and beyondIBI sequences support pulse-rate variability, PTT, and respiratory research.

A useful precision: when variability is measured from PPG pulse-to-pulse intervals, “pulse rate variability” is the most exact term. It is often used as an accessible approximation to ECG-derived heart-rate variability, but the two are not identical—especially during motion or changing vascular conditions.

Read the PulseSensor PPG and beat-detection explanation · Explore the open-source PulseSensor Playground library

Connecting the bibliography to open-source code

Where the PulseSensor Open Science library can go next

The existing PulseSensor Playground already supplies the essential real-time foundation: raw samples, beat detection, pulse amplitude, IBI, BPM, 500 Hz timing, multiple-sensor support, and visual or physical feedback. The older PulseSensor HRV collection also demonstrates time-domain, frequency-domain, Poincaré-plot, and biofeedback explorations.

Six practical additions suggested by Dr. Doyle’s bibliography

  • Research-ready waveform recorder. Export raw samples with exact timestamps, sensor location, sample rate, contact notes, and experiment markers. This creates the clean foundation repeatedly called for in papers 4, 7, 8, and 13.
  • Modern pulse-rate variability example. Calculate and explain IBI series, RMSSD, SDNN, frequency-domain summaries, and Poincaré plots while clearly distinguishing PPG-derived pulse-rate variability from ECG HRV. This could refresh the existing HRV sketches inside the main library.
  • “Find the breath” starter example. Derive RIAV from pulse amplitude, RIIV from the baseline, and RIFV from beat timing; then display the three candidate respiratory waves together. Papers 18, 20, 21, and 26 provide the scientific path.
  • Embedded respiration spectrum. Add bandpass filtering plus Welch/FFT peak detection as a transparent first algorithm, with an output confidence score and a reference comparison channel. Papers 23, 29, and 30 are especially practical.
  • Signal-quality gate. Label each analysis window “usable,” “questionable,” or “reject,” using pulse morphology and timing consistency before reporting BPM, HRV, or respiration. Start from papers 43, 44, and 45.
  • Motion and multi-sensor research examples. Synchronize multiple PulseSensors and optional accelerometer data, then preserve every channel for offline comparison. Papers 41, 42, and 47 show why this matters.

Recommended first milestone: combine the waveform recorder, signal-quality gate, and three-channel RIAV/RIIV/RIFV display. That would turn the current library’s dependable heartbeat engine into a reproducible PPG research starter kit without hiding the underlying science.

Applied PPG research with PulseSensor

Change the sensor, the person, the place and the motion

The waveform is not produced by the heart alone. It is the combined result of physiology, body site, optical wavelength, skin and tissue, sensor pressure, ambient light, movement, electronics, and the algorithm. Those variables are not merely problems to remove: when recorded carefully, they become the experiment.

What one to four PulseSensors can investigate

1One clean referenceRaw morphology, beat timing, IBI, BPM, pulse-rate variability, RIAV, RIIV, RIFV, respiration, pressure and motion tests at one site.
2Compare two sitesLeft hand vs. right hand, ear vs. finger, or two points along one limb. Compare amplitude, shape, respiratory content and relative pulse-arrival delay.
3Add a controlKeep one stable reference while comparing two sites, two pressures or two placements. A third channel can also carry a respiratory reference or motion signal.
4Build a body mapRecord bilateral fingers and ears—or another carefully documented set—to study site, symmetry, timing, motion and signal quality together.

Body position and placement

Finger, forehead, earlobe, upper wrist, underside of wrist and arm do not produce interchangeable PPG signals. Paper 13 found that the accuracy of PPG-derived respiratory frequency depended on both measurement site and breathing pattern; forehead performed best during normal breathing and finger during deep breathing in that study.

With two sensors—one on each hand—record side, finger, orientation, strap pressure and arm position. Compare signal quality, pulse shape, amplitude, respiratory modulation and relative arrival time rather than assuming that a difference is physiological.

Skin pigmentation and optical bias

Melanin, tissue thickness, perfusion, sensor geometry and wavelength can change how much light reaches the detector. Paper 4 treats skin tone as one of several interacting sources of PPG inaccuracy alongside contact pressure, ambient light, motion, sensor position and physiology.

An inclusive experiment should record a participant’s self-described skin tone or a documented scale, preserve raw signal amplitude and quality, and report failures—not silently discard difficult recordings. Do not treat a software threshold that works for one participant as universal.

Movement and contact noise

Motion can look like a pulse, shift the baseline, change pressure, and disturb every respiratory surrogate. Paper 41 uses simultaneous acceleration to help reconstruct motion-contaminated PPG. Papers 4345 support explicit signal-quality measures before reporting results.

Useful tests include stillness, tapping, hand rotation, walking and deliberate pressure changes. Record accelerometer data and experiment markers on the same clock as the PPG whenever possible.

Multiple colors and optical channels

Green, red and infrared light penetrate and scatter differently. Papers 42 and 47 show how multiple wavelengths and channels can help separate useful pulsatile information from motion. A normal PulseSensor provides one green optical channel; genuine multi-wavelength research requires additional red/infrared optical hardware, not merely multiple green PulseSensors.

Multiple ordinary PulseSensors are still valuable for spatial comparisons and redundancy. Label wavelength, LED drive, detector geometry and site for every channel.

Pulse arrival time and pulse transit time

Two PulseSensors placed at different distances from the heart can measure a relative pulse-arrival delay between two PPG waveforms. PulseSensor’s existing experiment places one sensor near the ear and one on a fingertip. If the distance between sites is measured and sampling is truly synchronized, the delay can support pulse-wave-travel experiments.

Important distinction: conventional pulse transit time usually begins at the heart’s electrical R-wave measured by ECG and ends at a peripheral PPG pulse. Two PPG sensors alone do not supply that ECG starting point; they measure the difference in arrival time between two peripheral sites. Changes may reflect vascular state, but they should not be presented as blood-pressure measurements or diagnoses without proper calibration and validation.

Explore the existing two-PulseSensor transit-time tutorial · See the open-source two-sensor example

Minimum record for every experiment

Save the raw waveform from every channel plus: exact sample timestamps, sensor and wavelength, body site and side, distance between sites when timing matters, attachment method and pressure, posture, breathing instruction, motion/accelerometer data, ambient-light notes, participant descriptors relevant to optical performance, signal-quality score, and the reference signal used for validation. That metadata is what lets another person reproduce—or challenge—the result.

Start here

Dr. Doyle’s suggested reading order

  1. Charlton et al. 2018 — the organizing framework
  2. Pimentel et al. 2017 — quality-aware fusion
  3. Karlen et al. 2013 — RIAV, RIIV and RIFV
  4. Dehkordi et al. 2018 — instantaneous respiratory rate
  5. Hartmann et al. 2019 — measurement-site effects
  6. Signal quality and motion — essential for wearables
  7. Modern algorithms and machine learning
  8. Wearable PPG roadmaps — where the field is going

Browse all 47 papers

Choose a topic

Every citation, author list, year, access label, direct paper link, and Dr. Doyle’s commentary appears below on this page.

Papers 1–8

Foundational PPG reviews and roadmaps

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01
2007Not clearly OA

Photoplethysmography and its application in clinical physiological measurement

Allen J

Allen J. Photoplethysmography and its application in clinical physiological measurement. Physiological Measurement. 2007;28(3):R1-R39. doi:10.1088/0967-3334/28/3/R01. PMID:17322588.

Why Dr. Doyle included it

A classic entry point for PPG physiology and instrumentation. It remains useful because respiratory extraction depends on understanding the arterial, venous, autonomic, optical-coupling, and site-related sources of waveform variation.

Open PubMed ↗
02
2018OA/PMC

A review on wearable photoplethysmography sensors and their potential future applications in health care

Castaneda D, Esparza A, Ghamari M, Soltanpur C, Nazeran H

Castaneda D, Esparza A, Ghamari M, Soltanpur C, Nazeran H. A review on wearable photoplethysmography sensors and their potential future applications in health care. International Journal of Biosensors & Bioelectronics. 2018;4(4):195-202. doi:10.15406/ijbsbe.2018.04.00125.

Why Dr. Doyle included it

Broad wearable-PPG review emphasizing sensor configurations, motion artifact, measurement site, and applications. Useful for choosing between finger, ear, forehead, wrist, and reflectance/transmission modes.

Open PMC ↗
03
2019OA/PMC

Current progress of photoplethysmography and SpO2 for health monitoring

Tamura T

Tamura T. Current progress of photoplethysmography and SpO2 for health monitoring. Biomedical Engineering Letters. 2019;9(1):21-36. doi:10.1007/s13534-019-00097-w. PMID:30956885.

Why Dr. Doyle included it

Concise review of PPG and pulse-oximetry technology, including motion artifacts and health-monitoring applications. A useful bridge between clinical pulse oximetry and consumer/wearable PPG.

Open PMC ↗
04
2021OA/PMC; CC BY

Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring

Fine J, Branan KL, Rodriguez AJ, Boonya-ananta T, Ajmal, Ramella-Roman JC, McShane MJ, Cote GL

Fine J, Branan KL, Rodriguez AJ, Boonya-ananta T, Ajmal, Ramella-Roman JC, McShane MJ, Cote GL. Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring. Biosensors (Basel). 2021;11(4):126. doi:10.3390/bios11040126. PMID:33923469.

Why Dr. Doyle included it

Highly relevant to experimental design. It catalogs sources of error including skin tone, motion, contact pressure, ambient light, sensor position, and physiology; all of these can corrupt respiratory-induced modulation.

Open PMC ↗
05
2022Free article / author manuscript

Photoplethysmography Signal Processing and Synthesis. In: Kyriacou PA, Allen J, editors. Photoplethysmography: Technology, Signal Analysis and Applications. Academic Press; 2022.

Mejia-Mejia E, Budidha K, Abay TY, May JM, Kyriacou PA

Mejia-Mejia E, Budidha K, Abay TY, May JM, Kyriacou PA. Photoplethysmography Signal Processing and Synthesis. In: Kyriacou PA, Allen J, editors. Photoplethysmography: Technology, Signal Analysis and Applications. Academic Press; 2022.

Why Dr. Doyle included it

Practical technical chapter on PPG preprocessing, time-domain analysis, frequency-domain analysis, machine learning, and synthetic signal generation. Valuable for moving from pulse counting to respiratory modulation extraction and simulator-driven testing.

Open Author PDF ↗
06
2022OA/PMC

Photoplethysmogram Analysis and Applications: An Integrative Review

Park J, Seok HS, Kim SS, Shin H

Park J, Seok HS, Kim SS, Shin H. Photoplethysmogram Analysis and Applications: An Integrative Review. Frontiers in Physiology. 2022;12:808451. doi:10.3389/fphys.2021.808451. PMID:35222266.

Why Dr. Doyle included it

Broad modern review of PPG analysis, physiology, and applications. It helps place respiratory extraction alongside HRV, blood pressure estimation, vascular assessment, autonomic analysis, and wearable sensing.

Open PMC ↗
07
2022OA/PMC; CC BY

Wearable Photoplethysmography for Cardiovascular Monitoring

Charlton PH, Kyriacou PA, Mant J, Marozas V, Chowienczyk P, Alastruey J

Charlton PH, Kyriacou PA, Mant J, Marozas V, Chowienczyk P, Alastruey J. Wearable Photoplethysmography for Cardiovascular Monitoring. Proceedings of the IEEE. 2022;110(3):355-381. doi:10.1109/JPROC.2022.3149785. PMID:35356509.

Why Dr. Doyle included it

High-value review for wearable and low-cost PPG systems. Covers sensor design, preprocessing, signal quality, datasets, and clinical use; essential background for respiratory algorithms in wearable conditions.

Open PMC ↗
08
2023OA/PMC

The 2023 wearable photoplethysmography roadmap

Charlton PH, et al

Charlton PH, et al. The 2023 wearable photoplethysmography roadmap. Physiological Measurement. 2023;44(11):111001. doi:10.1088/1361-6579/acead2. PMID:37494945.

Why Dr. Doyle included it

Strategic roadmap for wearable PPG research: sensor design, signal processing, clinical translation, datasets, bias, and open science. Strong reference for building an open Arduino/ESP32 PPG platform. Respiratory physiology and PPG modulation

Open PMC ↗

Papers 9–15

Respiratory physiology and PPG modulation

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09
2012Free article / author PDF; not publisher OA confirmed

Photoplethysmographic derivation of respiratory rate: a review of relevant physiology

Meredith DJ, Clifton D, Charlton PH, Brooks J, Pugh CW, Tarassenko L

Meredith DJ, Clifton D, Charlton PH, Brooks J, Pugh CW, Tarassenko L. Photoplethysmographic derivation of respiratory rate: a review of relevant physiology. Journal of Medical Engineering & Technology. 2012;36(1):1-7. doi:10.3109/03091902.2011.638965. PMID:22185462.

Why Dr. Doyle included it

Foundational physiological review explaining how breathing modulates PPG through venous return, intrathoracic pressure, autonomic effects, and respiratory sinus arrhythmia. Justifies parallel extraction of RIIV, RIAV, and RIFV.

Open Author PDF ↗
10
2013Not clearly OA

Respiration signals from photoplethysmography

Nilsson LM

Nilsson LM. Respiration signals from photoplethysmography. Anesthesia & Analgesia. 2013;117(4):859-865. doi:10.1213/ANE.0b013e31828098b2. PMID:23449854.

Why Dr. Doyle included it

Clinically oriented review from anesthesia and monitoring. Particularly relevant to OR and procedural settings where pulse oximetry is already present and respiration monitoring may be desirable without extra sensors.

Open PubMed ↗
11
2010Not clearly OA

Comparison of respiratory-induced variations in photoplethysmographic signals

Li J, Jin J, Chen X, Sun W, Guo P

Li J, Jin J, Chen X, Sun W, Guo P. Comparison of respiratory-induced variations in photoplethysmographic signals. Physiological Measurement. 2010;31(3):415-425. doi:10.1088/0967-3334/31/3/009. PMID:20147775.

Why Dr. Doyle included it

Important comparison of respiratory-induced PPG variations. Supports storing raw waveform data so that multiple modulation families can be compared offline rather than relying on one respiratory surrogate.

Open PubMed ↗
12
2020Not clearly OA

Comparison of different modulations of photoplethysmography in extracting respiratory rate: from a physiological perspective

Liu H, et al

Liu H, et al. Comparison of different modulations of photoplethysmography in extracting respiratory rate: from a physiological perspective. Physiological Measurement. 2020;41(9):094001. doi:10.1088/1361-6579/abaaf0. PMID:32731213.

Why Dr. Doyle included it

Corrected title. Useful because it frames respiratory extraction in terms of physiological mechanisms rather than numerical performance alone. It reminds developers that amplitude, baseline, and frequency modulation may fail under different conditions.

Open PubMed ↗
13
2019OA/PMC

Toward Accurate Extraction of Respiratory Frequency From the Photoplethysmogram: Effect of Measurement Site

Hartmann V, Liu H, Chen F, Qiu Q, Hughes S, Zheng D

Hartmann V, Liu H, Chen F, Qiu Q, Hughes S, Zheng D. Toward Accurate Extraction of Respiratory Frequency From the Photoplethysmogram: Effect of Measurement Site. Frontiers in Physiology. 2019;10:732. doi:10.3389/fphys.2019.00732. PMID:31316390.

Why Dr. Doyle included it

Directly relevant to hardware design. Shows that PPG-derived respiratory frequency depends on measurement site and breathing pattern; strongly supports testing multiple sensor locations or optical channels.

Open PMC ↗
14
2016OA/PMC

Respiratory modulations in the photoplethysmogram (DPOP) as a measure of respiratory effort

Addison PS

Addison PS. Respiratory modulations in the photoplethysmogram (DPOP) as a measure of respiratory effort. Journal of Clinical Monitoring and Computing. 2016;30(5):595-602. doi:10.1007/s10877-015-9763-y. PMID:26377021.

Why Dr. Doyle included it

Useful for moving beyond respiratory rate toward respiratory effort. DPOP quantifies the strength of respiratory modulation in the pleth waveform; a platform should consider modulation depth as well as rate.

Open PMC ↗
15
2017Free article

Respiratory effort from the photoplethysmogram

Addison PS

Addison PS. Respiratory effort from the photoplethysmogram. Medical Engineering & Physics. 2017;41:9-18. doi:10.1016/j.medengphy.2016.12.010. PMID:28126420.

Why Dr. Doyle included it

Explores candidate PPG-derived parameters for respiratory effort, including amplitude, baseline, frequency, and pulse-transit-related changes. Suggests richer endpoints than respiratory rate alone. Classical and advanced algorithmic extraction of respiration from PPG

Open PubMed ↗

Papers 16–31

Algorithms for extracting respiration

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16
1996Not clearly OA

Monitoring of heart and respiratory rates by photoplethysmography using a digital filtering technique

Nakajima K, Tamura T, Miike H

Nakajima K, Tamura T, Miike H. Monitoring of heart and respiratory rates by photoplethysmography using a digital filtering technique. Medical Engineering & Physics. 1996;18(5):365-372. doi:10.1016/1350-4533(95)00066-6. PMID:8762834.

Why Dr. Doyle included it

Historically important early demonstration that both heart and respiratory rates can be extracted from PPG with digital filtering. Dated technologically, but conceptually useful as a simple baseline.

Open PubMed ↗
17
2009Free article / author PDF found; not publisher OA confirmed

Estimation of respiratory rate from photoplethysmogram data using time-frequency spectral estimation

Chon KH, Dash S, Ju K

Chon KH, Dash S, Ju K. Estimation of respiratory rate from photoplethysmogram data using time-frequency spectral estimation. IEEE Transactions on Biomedical Engineering. 2009;56(8):2054-2063. doi:10.1109/TBME.2009.2019766. PMID:19369147.

Why Dr. Doyle included it

Key paper in the transition from simple filtering to time-frequency spectral estimation. Important for nonstationary breathing; a good offline benchmark against cheaper embedded algorithms.

Open PubMed ↗
18
2013Not clearly OA

Multiparameter respiratory rate estimation from the photoplethysmogram

Karlen W, Raman S, Ansermino JM, Dumont GA

Karlen W, Raman S, Ansermino JM, Dumont GA. Multiparameter respiratory rate estimation from the photoplethysmogram. IEEE Transactions on Biomedical Engineering. 2013;60(7):1946-1953. doi:10.1109/TBME.2013.2246160. PMID:23399950.

Why Dr. Doyle included it

Central paper for PPG-derived respiratory rate. It extracts respiratory-induced frequency, intensity, and amplitude variations and combines information across them; highly relevant to a multi-channel platform.

Open PubMed ↗
19
2016OA/PMC; CC BY

An assessment of algorithms to estimate respiratory rate from the electrocardiogram and photoplethysmogram

Charlton PH, Bonnici T, Tarassenko L, Clifton DA, Beale R, Watkinson PJ

Charlton PH, Bonnici T, Tarassenko L, Clifton DA, Beale R, Watkinson PJ. An assessment of algorithms to estimate respiratory rate from the electrocardiogram and photoplethysmogram. Physiological Measurement. 2016;37(4):610-626. doi:10.1088/0967-3334/37/4/610. PMID:27027672.

Why Dr. Doyle included it

Methodological cornerstone comparing algorithms and emphasizing validation, data quality, and common evaluation methods. Important antidote to overfitting algorithms to one clean dataset.

Open PMC ↗
20
2017OA/PMC; CC BY

Toward a Robust Estimation of Respiratory Rate From Pulse Oximeters

Pimentel MAF, Johnson AEW, Charlton PH, Birrenkott D, Watkinson PJ, Tarassenko L, Clifton DA

Pimentel MAF, Johnson AEW, Charlton PH, Birrenkott D, Watkinson PJ, Tarassenko L, Clifton DA. Toward a Robust Estimation of Respiratory Rate From Pulse Oximeters. IEEE Transactions on Biomedical Engineering. 2017;64(8):1914-1923. doi:10.1109/TBME.2016.2613124. PMID:28113393.

Why Dr. Doyle included it

Must-read for robust RR estimation from pulse oximetry. Uses respiratory-induced variations, quality assessment, and probabilistic fusion; one of the best algorithmic templates for a practical platform.

Open PMC ↗
21
2018OA/PMC; CC BY

Breathing Rate Estimation From the Electrocardiogram and Photoplethysmogram: A Review

Charlton PH, Birrenkott DA, Bonnici T, Pimentel MAF, Johnson AEW, Alastruey J, Tarassenko L, Watkinson PJ, Beale R, Clifton DA

Charlton PH, Birrenkott DA, Bonnici T, Pimentel MAF, Johnson AEW, Alastruey J, Tarassenko L, Watkinson PJ, Beale R, Clifton DA. Breathing Rate Estimation From the Electrocardiogram and Photoplethysmogram: A Review. IEEE Reviews in Biomedical Engineering. 2018;11:2-20. doi:10.1109/RBME.2017.2763681. PMID:29990026.

Why Dr. Doyle included it

The best single review for breathing-rate estimation from ECG and PPG. Lays out preprocessing, respiratory-signal extraction, rate estimation, fusion, and quality assessment.

Open PMC ↗
22
2014OA/PMC / PLOS

Estimating respiratory and heart rates from the correntropy spectral density of the photoplethysmogram

Garde A, Karlen W, Ansermino JM, Dumont GA

Garde A, Karlen W, Ansermino JM, Dumont GA. Estimating respiratory and heart rates from the correntropy spectral density of the photoplethysmogram. PLOS ONE. 2014;9(1):e86427. doi:10.1371/journal.pone.0086427. PMID:24466088.

Why Dr. Doyle included it

Corrected author list: Dehkordi was removed. Uses correntropy spectral density to improve robustness to noise and non-Gaussian artifacts; useful when simple FFT/Welch methods are unreliable.

Open PMC ↗
23
2014OA/PMC / BioMed Central

Real-time estimation of respiratory rate from a photoplethysmogram using an adaptive lattice notch filter

Park C, Lee B, Lee J

Park C, Lee B, Lee J. Real-time estimation of respiratory rate from a photoplethysmogram using an adaptive lattice notch filter. BioMedical Engineering OnLine. 2014;13:170. doi:10.1186/1475-925X-13-170. PMID:25518918.

Why Dr. Doyle included it

Corrected title and venue. Valuable for real-time feasibility: algorithms that work in MATLAB may be too memory- or CPU-intensive for an embedded device.

Open PMC ↗
24
2016Not clearly OA

Respiratory rate monitoring from the photoplethysmogram via sparse signal reconstruction

Zhang X, Ding Q

Zhang X, Ding Q. Respiratory rate monitoring from the photoplethysmogram via sparse signal reconstruction. Physiological Measurement. 2016;37(7):1105-1119. doi:10.1088/0967-3334/37/7/1105. PMID:27319303.

Why Dr. Doyle included it

Corrected full citation. Treats respiration as a sparse spectral component embedded in a stronger cardiac carrier and noise; likely more useful as an offline benchmark than a first Arduino algorithm.

Open PubMed ↗
25
2015Not clearly OA

Estimating instantaneous respiratory rate from the photoplethysmogram

Dehkordi P, Garde A, Karlen W, Ansermino JM, Dumont GA

Dehkordi P, Garde A, Karlen W, Ansermino JM, Dumont GA. Estimating instantaneous respiratory rate from the photoplethysmogram. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2015;2015:6150-6153. doi:10.1109/EMBC.2015.7319796. PMID:26737696.

Why Dr. Doyle included it

Corrected conference citation. Introduces a synchrosqueezing-transform direction for instantaneous respiratory-rate extraction; likely too heavy for first-pass embedded use but a valuable offline standard.

Open PubMed ↗
26
2018OA/PMC

Extracting Instantaneous Respiratory Rate From Multiple Photoplethysmogram Respiratory-Induced Variations

Dehkordi P, Garde A, Karlen W, Wensley D, Ansermino JM, Dumont GA

Dehkordi P, Garde A, Karlen W, Wensley D, Ansermino JM, Dumont GA. Extracting Instantaneous Respiratory Rate From Multiple Photoplethysmogram Respiratory-Induced Variations. Frontiers in Physiology. 2018;9:948. doi:10.3389/fphys.2018.00948. PMID:30131724.

Why Dr. Doyle included it

Central open-access paper for advanced respiratory extraction. Extracts RIIV, RIAV, and RIFV, estimates instantaneous RR from each, and fuses estimates.

Open PMC ↗
27
2017OA/PMC

How nonlinear-type time-frequency analysis can help in sensing instantaneous heart rate and instantaneous respiratory rate from photoplethysmography in a reliable way

Cicone A, Wu HT

Cicone A, Wu HT. How nonlinear-type time-frequency analysis can help in sensing instantaneous heart rate and instantaneous respiratory rate from photoplethysmography in a reliable way. Frontiers in Physiology. 2017;8:701. doi:10.3389/fphys.2017.00701. PMID:29018395.

Why Dr. Doyle included it

Mathematically advanced nonlinear time-frequency analysis for instantaneous heart and respiratory rates. Not a first embedded method, but useful as a high-end reference standard.

Open PMC ↗
28
2020Not clearly OA

Breathing Rate Estimation Using Kalman Smoother With Electrocardiogram and Photoplethysmogram

Khreis S, Ge D, Rahman HA, Carrault G

Khreis S, Ge D, Rahman HA, Carrault G. Breathing Rate Estimation Using Kalman Smoother With Electrocardiogram and Photoplethysmogram. IEEE Transactions on Biomedical Engineering. 2020;67(3):893-904. doi:10.1109/TBME.2019.2923448. PMID:31217092.

Why Dr. Doyle included it

Shows the value of temporal tracking/smoothing for breath-rate estimates. A Kalman or Bayesian smoother is a natural second-stage module after raw estimator extraction.

Open PubMed ↗
29
2022OA/PMC

Photoplethysmography-Based Respiratory Rate Estimation Algorithm for Health Monitoring Applications

Iqbal T, Elahi A, Ganly S, Wijns W, Shahzad A

Iqbal T, Elahi A, Ganly S, Wijns W, Shahzad A. Photoplethysmography-Based Respiratory Rate Estimation Algorithm for Health Monitoring Applications. Journal of Medical and Biological Engineering. 2022;42(2):242-252. doi:10.1007/s40846-022-00700-z. PMID:35535218.

Why Dr. Doyle included it

Corrected full citation. Practical algorithm using selective windowing, preprocessing, modified Welch filtering, and postprocessing. A useful baseline because it is less exotic than synchrosqueezing but more robust than simple filtering.

Open PMC ↗
30
2016OA/PMC / MDPI

Fast and Robust Real-Time Estimation of Respiratory Rate from Photoplethysmography

Kim H, Lee HJ, Kim JS, Whang MC

Kim H, Lee HJ, Kim JS, Whang MC. Fast and Robust Real-Time Estimation of Respiratory Rate from Photoplethysmography. Sensors (Basel). 2016;16(9):1494. doi:10.3390/s16091494. PMID:27649195.

Why Dr. Doyle included it

Added as a useful correction/augmentation. Proposes fast real-time RR estimation from PPG, relevant to low-resource embedded implementations and comparison with Park-style adaptive filtering.

Open PMC ↗
31
2018OA/PMC / MDPI

Acquiring Respiration Rate from Photoplethysmographic Signal by Recursive Bayesian Tracking of Intrinsic Modes in Time-Frequency Spectra

Pirhonen M, Peltokangas M, Vehkaoja A

Pirhonen M, Peltokangas M, Vehkaoja A. Acquiring Respiration Rate from Photoplethysmographic Signal by Recursive Bayesian Tracking of Intrinsic Modes in Time-Frequency Spectra. Sensors (Basel). 2018;18(6):1693. doi:10.3390/s18061693. PMID:29843380.

Why Dr. Doyle included it

Useful open-access time-frequency/Bayesian tracking paper. It broadens the algorithmic menu beyond RIAV/RIIV/RIFV and standard spectral peaks. Machine learning, deep learning, signal quality, and robustness

Open PMC ↗

Papers 32–47

Machine learning, signal quality, and robustness

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32
2021OA/PMC / PLOS

Determining respiratory rate from photoplethysmogram and electrocardiogram signals using respiratory quality indices and neural networks

Baker S, Xiang W, Atkinson I

Baker S, Xiang W, Atkinson I. Determining respiratory rate from photoplethysmogram and electrocardiogram signals using respiratory quality indices and neural networks. PLOS ONE. 2021;16(4):e0249843. doi:10.1371/journal.pone.0249843. PMID:33891653.

Why Dr. Doyle included it

Strong bridge between classical modulation extraction and neural networks. Emphasizes respiratory signal quality quantification before feeding information into models.

Open PMC ↗
33
2020OA/PMC / MDPI

Estimation of Heart Rate and Respiratory Rate from PPG Signal Based on Complementary Ensemble Empirical Mode Decomposition with Adaptive Noise and Independent Component Analysis

Lei R, Chen C, Zhou C, Zhang Y, Yang Z, Wang X

Lei R, Chen C, Zhou C, Zhang Y, Yang Z, Wang X. Estimation of Heart Rate and Respiratory Rate from PPG Signal Based on Complementary Ensemble Empirical Mode Decomposition with Adaptive Noise and Independent Component Analysis. Sensors (Basel). 2020;20(11):3237. doi:10.3390/s20113237. PMID:32517009.

Why Dr. Doyle included it

Uses decomposition and source-separation style processing to recover heart and respiratory rates. Useful for comparing EMD/ICA approaches with simpler bandpass methods.

Open PMC ↗
34
2022OA/PMC / MDPI

Lightweight End-to-End Deep Learning Solution for Estimating the Respiration Rate from Photoplethysmogram Signal

Chowdhury MH, Shuzan MNI, Chowdhury MEH, Reaz MBI, Mahmud S, Al Emadi N, et al

Chowdhury MH, Shuzan MNI, Chowdhury MEH, Reaz MBI, Mahmud S, Al Emadi N, et al. Lightweight End-to-End Deep Learning Solution for Estimating the Respiration Rate from Photoplethysmogram Signal. Bioengineering (Basel). 2022;9(10):558. doi:10.3390/bioengineering9100558.

Why Dr. Doyle included it

Corrected title and venue. Useful as a benchmark for direct RR estimation from raw/processed PPG, even if a full deep model is not the first target for Arduino deployment.

Open PMC ↗
35
2023OA/PMC / MDPI

Evaluation of the Photoplethysmogram-Based Deep Learning Model for Respiratory Rate Estimation

Hwang CS, et al

Hwang CS, et al. Evaluation of the Photoplethysmogram-Based Deep Learning Model for Respiratory Rate Estimation. Sensors (Basel). 2023;23(20):8377. doi:10.3390/s23208377. PMID:37892952.

Why Dr. Doyle included it

Corrected to a specific Sensors article. Evaluates deep learning models for continuous RR estimation from PPG and helps identify what labeled respiratory reference signal would be needed for training or validation.

Open PMC ↗
36
2023OA/PMC; CC BY

Machine Learning-Based Respiration Rate and Blood Oxygen Saturation Estimation Using Photoplethysmogram Signals

Shuzan MNI, Chowdhury MH, Chowdhury MEH, Murugappan M, Bhuiyan EH, Ayari MA, Khandakar A

Shuzan MNI, Chowdhury MH, Chowdhury MEH, Murugappan M, Bhuiyan EH, Ayari MA, Khandakar A. Machine Learning-Based Respiration Rate and Blood Oxygen Saturation Estimation Using Photoplethysmogram Signals. Bioengineering (Basel). 2023;10(2):167. doi:10.3390/bioengineering10020167. PMID:36829661.

Why Dr. Doyle included it

Machine-learning approach to estimating both RR and SpO2-related information from PPG. Suggests future multi-output models that estimate RR, signal quality, SpO2 surrogates, and artifact flags.

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37
2024OA/PMC / MDPI

A novel respiratory rate estimation algorithm from photoplethysmogram using deep learning model

Chin WJ, Kwan BH, Lim WY, Tee YK, Darmaraju S, Liu H, Goh CH

Chin WJ, Kwan BH, Lim WY, Tee YK, Darmaraju S, Liu H, Goh CH. A novel respiratory rate estimation algorithm from photoplethysmogram using deep learning model. Diagnostics (Basel). 2024;14(3):284. doi:10.3390/diagnostics14030284. PMID:38337800.

Why Dr. Doyle included it

Corrected title. Recent open-access paper explicitly focused on RR from PPG; useful contemporary comparator and bridge to older RIAV/RIIV/RIFV methods.

Open PMC ↗
38
2024OA/PMC / MDPI; CC BY

Energy-Efficient PPG-Based Respiratory Rate Estimation Using Spiking Neural Networks

Yang G, Kang Y, Charlton PH, Kyriacou PA, Kim KK, Li L, Park C

Yang G, Kang Y, Charlton PH, Kyriacou PA, Kim KK, Li L, Park C. Energy-Efficient PPG-Based Respiratory Rate Estimation Using Spiking Neural Networks. Sensors (Basel). 2024;24(12):3980. doi:10.3390/s24123980. PMID:38931569.

Why Dr. Doyle included it

Relevant for low-power and embedded ambitions. Spiking neural networks may eventually map well to efficient hardware, even if not immediately Arduino-friendly.

Open PMC ↗
39
2024OA/PMC / Heliyon

The use of successive systolic differences in photoplethysmography for respiratory rate estimation

Arguello-Prada EJ, et al

Arguello-Prada EJ, et al. The use of successive systolic differences in photoplethysmography for respiratory rate estimation. Heliyon. 2024;10(2):e24576. doi:10.1016/j.heliyon.2024.e24576.

Why Dr. Doyle included it

Introduces respiratory-induced variations in successive systolic differences as an alternative to classic amplitude, intensity, and frequency families; valuable for beat-to-beat morphology-oriented experiments.

Open PMC ↗
40
2025OA/PMC / MDPI

Comparison of Techniques for Respiratory Rate Extraction from ECG and PPG Signals

Ponsiglione AM, et al

Ponsiglione AM, et al. Comparison of Techniques for Respiratory Rate Extraction from ECG and PPG Signals. Sensors (Basel). 2025;25(16):5136. doi:10.3390/s25165136. PMID:40871998.

Why Dr. Doyle included it

Recent comparative paper evaluating extraction from ECG and PPG. Useful for sober benchmarking and for recognizing conditions where PPG-derived respiration may underperform ECG-derived features.

Open PMC ↗
41
2019OA/PMC

Estimation of Respiratory Rate from Motion Contaminated Photoplethysmography Signals Incorporating Accelerometry

Jarchi D, Charlton PH, Pimentel MAF, Casson AJ, Tarassenko L, Clifton DA

Jarchi D, Charlton PH, Pimentel MAF, Casson AJ, Tarassenko L, Clifton DA. Estimation of Respiratory Rate from Motion Contaminated Photoplethysmography Signals Incorporating Accelerometry. Healthcare Technology Letters. 2019;6(1):19-24. doi:10.1049/htl.2018.5019.

Why Dr. Doyle included it

Corrected full title. Motion-contaminated PPG is the normal wearable case; supports adding accelerometers and explicit motion labels to the platform.

Open PMC ↗
42
2020OA/PMC / MDPI

Motion Artifact Reduction in Wearable Photoplethysmography Based on Multi-Channel Sensors with Multiple Wavelengths

Lee J, Kim M, Park HK, Kim IY

Lee J, Kim M, Park HK, Kim IY. Motion Artifact Reduction in Wearable Photoplethysmography Based on Multi-Channel Sensors with Multiple Wavelengths. Sensors (Basel). 2020;20(5):1493. doi:10.3390/s20051493.

Why Dr. Doyle included it

Directly relevant to hardware. Supports multi-channel and multi-wavelength PPG sensors for artifact reduction; useful for separating respiratory physiology from motion and contact artifacts.

Open PMC ↗
43
2016OA/PMC

Optimal Signal Quality Index for Photoplethysmogram Signals

Elgendi M

Elgendi M. Optimal Signal Quality Index for Photoplethysmogram Signals. Bioengineering (Basel). 2016;3(4):21. doi:10.3390/bioengineering3040021. PMID:28952542.

Why Dr. Doyle included it

Key open paper on PPG signal-quality indices. Respiratory extraction is only as reliable as the source waveform; supports quality gating before RR estimation.

Open PMC ↗
44
2019OA/PMC

Signal quality measure for pulsatile physiological signals using morphological features: Applications in reliability measure for pulse oximetry

Sabeti E, Reamaroon N, Mathis J, et al

Sabeti E, Reamaroon N, Mathis J, et al. Signal quality measure for pulsatile physiological signals using morphological features: Applications in reliability measure for pulse oximetry. Informatics in Medicine Unlocked. 2019;16:100222. doi:10.1016/j.imu.2019.100222. PMID:32864419.

Why Dr. Doyle included it

Corrected title and application phrase. Proposes morphological features for signal quality and reliability, which can support exclusion/down-weighting of unreliable PPG windows.

Open PMC ↗
45
2015Not clearly OA

Signal-quality indices for the electrocardiogram and photoplethysmogram: derivation and applications to wireless monitoring

Orphanidou C, Bonnici T, Charlton P, Clifton D, Vallance D, Tarassenko L

Orphanidou C, Bonnici T, Charlton P, Clifton D, Vallance D, Tarassenko L. Signal-quality indices for the electrocardiogram and photoplethysmogram: derivation and applications to wireless monitoring. IEEE Journal of Biomedical and Health Informatics. 2015;19(3):832-838. doi:10.1109/JBHI.2014.2338351. PMID:25069129.

Why Dr. Doyle included it

Highly cited SQI paper in wearable monitoring. Reinforces that signal quality is task-specific: a segment may be adequate for heart rate but not for respiratory information.

Open PubMed ↗
46
2016OA/PMC

Robust respiration detection from remote photoplethysmography

van Gastel M, Stuijk S, de Haan G

van Gastel M, Stuijk S, de Haan G. Robust respiration detection from remote photoplethysmography. Biomedical Optics Express. 2016;7(12):4941-4957. doi:10.1364/BOE.7.004941. PMID:28018717.

Why Dr. Doyle included it

Remote/camera-based PPG paper relevant because it extracts respiration from color/intensity variations and addresses motion robustness. Broadens the project from contact PPG to optical/camera respiratory sensing.

Open PMC ↗
47
2019OA/PMC / MDPI

Motion Artifact Reduction for Wrist-Worn Photoplethysmograph Sensors Based on Different Wavelengths

Zhang Y, Song S, Vullings R, Biswas D, Simões-Capela N, Van Helleputte N, Van Hoof C, Groenendaal W

Zhang Y, Song S, Vullings R, Biswas D, Simões-Capela N, Van Helleputte N, Van Hoof C, Groenendaal W. Motion Artifact Reduction for Wrist-Worn Photoplethysmograph Sensors Based on Different Wavelengths. Sensors (Basel). 2019;19(3):673. doi:10.3390/s19030673. PMID:30764575.

Why Dr. Doyle included it

Useful adjunct for multi-wavelength hardware design. Although focused mainly on heart-rate recovery, the motion-removal logic matters for any respiratory estimator using wearable PPG.

Open MDPI ↗

Notes for a PulseSensor / Arduino / ESP32 platform

Move from reading to experimentation

Begin with bandpass filtering and Welch/FFT respiratory peak detection; extract RIAV, RIIV, and RIFV; add simple fusion or median selection; add signal-quality gating; and compare with a reference respiratory signal where available. Plan for accelerometer integration and multi-wavelength sensors to combat artifacts.

Corrected annotated bibliography revised July 8, 2026. Prepared with AI assistance; readers should independently verify citations and licensing before reproducing figures or tables. Working page marker: research_G.